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inavolisib (gdc-0077)  (Genentech inc)

 
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    Genentech inc inavolisib (gdc-0077)
    Inavolisib (Gdc 0077), supplied by Genentech inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/inavolisib(gdc-0077)/inavolisib/pmc11939116-319-11-3
    Average 90 stars, based on 1 article reviews
    inavolisib (gdc-0077) - by Bioz Stars, 2026-09
    90/100 stars

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    other:

    Article Title: Identification of phytomolecules as isoform and mutation specific PI3K-α inhibitor for protection against breast cancer using e-pharmacophore modeling and molecular dynamics simulations.
    Article Snippet: In: Proceedings of the 2006 ACM/IEEE Conference on Supercomputing. pp 84-es 34. GenenTech: Our Pipeline - Inavolisib (GDC-0077). https:// www. gene. com/ medic al- profe ssion als/ pipel ine/ inavo lisib- gdc- 0077# inavo lisib- gdc- 0077- hr- her2- negat ive- pik3ca- mutat ed- mbc- post- cdk46i- thera py- inavo 121 35.



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    Inhibition of cervical cancer cell lines by PI3K α inhibitors. The maximum dose for each cell line was selected, and the percentage inhibition was compared with the corresponding control. (A) Alpelisib (BYL-719). (B) Inavolisib (GDC-0077). All cell lines have PIK3CA mutations except SiHa. **** = p < 0.0001 by one-way ANOVA and Dunnett’s multiple comparison test. <20% inhibition interpreted as no or negative response.

    Journal: Neoplasia (New York, N.Y.)

    Article Title: PIK3CA mutant cervical cancer is selectively suppressed by PI3Kα inhibition (Alpelisib/BYL-719 and Inavolisib/GDC-0077) and cooperates with HPV directed T cell therapy

    doi: 10.1016/j.neo.2026.101305

    Figure Lengend Snippet: Inhibition of cervical cancer cell lines by PI3K α inhibitors. The maximum dose for each cell line was selected, and the percentage inhibition was compared with the corresponding control. (A) Alpelisib (BYL-719). (B) Inavolisib (GDC-0077). All cell lines have PIK3CA mutations except SiHa. **** = p < 0.0001 by one-way ANOVA and Dunnett’s multiple comparison test. <20% inhibition interpreted as no or negative response.

    Article Snippet: GDC-0077 was also purchased from MedChem Express (Cat# HY-101562.

    Techniques: Inhibition, Control, Comparison